Henrotin, Yves, Ali Mobasheri, and Marc Marty. “Is There Any Scientific Evidence for the Use of Glucosamine in the Management of Human Osteoarthritis?” Arthritis Research & Therapy 14.1 (2012): 201. PMC. Web. 14 Oct. 2016.

Glucosamine and Chondroitin Sulfate: Scientific Evaluation - FDA.

Hochberg, M. C. et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: A multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Ann. Rheum. Dis. (2015).


Conroizer, T. Chondroitin sulfates (CS 4&6): efficacy and tolerance. Presse Medicale v. 27 Issue 36 Published Nov. 1998.

Hochberg, M. C. et al. Combined chondroitin sulfate and glucosamine for painful knee osteoarthritis: A multicentre, randomised, double-blind, non-inferiority trial versus celecoxib. Ann. Rheum. Dis. (2015).

Mazeieres B et. al Chondroitin sulfate in the treatment of gonarthrosis and coxarthrosis. 5-months result of a multi center double-blind controlled prospective study using placebo. Rev Rhum Mal Osteoartic. 1992 July-Sep; 59(7-8):466-72.


Engelke UF, Tangerman A, Willemsen MA, Moskau D, Loss S, Mudd SH, Wevers RA. Dimethyl sulfone in human cerebrospinal fluid and blood plasma confirmed by onedimensional (1)H and two-dimensional (1)H-(13)C NMR. NMR Biomed 2005; 18: 331-336.

Kim, L.S. et al. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage , Volume 14 , Issue 3 , 286 - 294.

Nakhostin-Roohi B, Barmaki S, Khoshkhahesh F, et al. Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men. J Pharm.Pharmacol. 2011;63(10):1290-1294.

4Boswellia Serrata

Maroon, Joseph C., Jeffrey W. Bost, and Adara Maroon. “Natural Anti-Inflammatory Agents for Pain Relief.” Surgical Neurology International 1 (2010): 80. PMC. Web. 14 Oct. 2016.

Siddiqui, M. Z. “Boswellia Serrata, A Potential Antiinflammatory Agent: An Overview.” Indian Journal of Pharmaceutical Sciences 73.3 (2011): 255–261. PMC. Web. 14 Oct. 2016.

Vishal AA, Mishra A, Raychaudhuri SP. A Double Blind, Randomized, Placebo Controlled Clinical Study Evaluates the Early Efficacy of Aflapin® in Subjects with Osteoarthritis of Knee. Int J Med Sci 2011; 8(7):615-622. doi:10.7150/ijms.8.615.

Earnst. E. “Frankincense: systematic review” BMJ 2008;337:a2813.

5Hyaluronic Acid

Balazs EA, Watson D, Duff IF, Roseman S. Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritic human fluids. Arthritis Rheum. 1967;10:357–76.

Bagga H, Burkhardt D, Sambrook P, March L. Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee. J Rheumatol. 2006;33:946–50.

Mariko Oe et. al. Oral hyaluronan relieves knee pain: a review. Nutrition Journal 2016 10.1186/s12937-016-0128-2


Gupta, Subash C., Sridevi Patchva, and Bharat B. Aggarwal. “Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials.” The AAPS Journal 15.1 (2013): 195–218. PMC. Web. 17 Oct. 2016.

Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012;26(11):1719–25. doi:10.1002/ptr.4639.

Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, et al. Product-evaluation registry of Meriva(R), a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 2010;52(2 Suppl 1):55–62.

7Collagen Type II

Lugo, James P. et. al. Indentured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers. Journal of the International Society of Sports Nutrition 2013 10:48 DOI: 10.1186/1550-2783-10-48.

Crowley, David C. et al. “Safety and Efficacy of Undenatured Type II Collagen in the Treatment of Osteoarthritis of the Knee: A Clinical Trial.” International Journal of Medical Sciences 6.6 (2009): 312–321.

Bagchi D, Misner B, Bagchi M, Kothari SC, Downs BW, Fafard RD, Preuss HG. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. Int J Clin Pharmacol Res. 2002;22(3-4):101–10.

8Proteolytic Enzymes

Brien, Sarah et al. “Bromelain as a Treatment for Osteoarthritis: A Review of Clinical Studies.” Evidence-based Complementary and Alternative Medicine 1.3 (2004): 251–257. PMC. Web. 17 Oct. 2016.

Beck TW, Housh TJ, Johnson GO, et al. Effects of a protease supplement on eccentric exercise-induced markers of delayed-onset muscle soreness and muscle damage. J Strength Cond Res. 2007;21:661-667.

Stone MB, Merrick MA, Ingersoll CD, et al. Preliminary comparison of bromelain and ibuprofen for delayed onset muscle soreness management. Clin J Sport Med. 2002;12:373-378.


9TEA Salicylate

Matthews, Paul et al. “Topical Rubefacients for Acute and Chronic Pain in Adults.” The Cochrane database of systematic reviews 3 (2009): CD007403. PMC. Web. 17 Oct. 2016.


Martin Bauer, Richard Schwameis, Thomas Scherzer, Isabelle Lang-Zwosta, Kanako Nishino, and Markus Zeitlinger. A double-blind, randomized clinical study to determine the efficacy of benzocaine 10% on histamine-induced pruritus and UVB-light induced slight sunburn pain. Journal of Dermatological Treatment, Vol. 26 , Iss. 4,2015.

Hersh, Elliot V. et al. “An Evaluation of 10 Percent and 20 Percent Benzocaine Gels in Patients with Acute Toothaches: Efficacy, Tolerability and Compliance with Label Dose Administration Directions.” Journal of the American Dental Association (1939) 144.5 (2013): 517–526.

Guleyupoglu, Berkan. Reduced discomfort during high-definition transcutaneous stimulation using 6% benzocaine. Front. Neuroeng., 11 July 2014

11Aloe Vera Gel

Gupta, Vinay K., and Seema Malhotra. “Pharmacological Attribute of Aloe Vera: Revalidation through Experimental and Clinical Studies.” Ayu 33.2 (2012): 193–196. PMC. Web. 17 Oct. 2016.

Eshghi, Fariborz, Hosseinimehr, Seyed Jalal et. al. Effects of Aloe vera Cream on Posthemorrhoidectomy Pain and Wound Healing: Results of a Randomized, Blind, Placebo-Control Study. Journal of alternative and complementary medicine (New York, N.Y.) react-text: 50 16(6):647-50.


Peppin, John F. et al. “Skin Matters: A Review of Topical Treatments for Chronic Pain. Part Two: Treatments and Applications.” Pain and Therapy 4.1 (2015): 33–50. PMC. Web. 17 Oct. 2016.

Massey, Thomas et al. “Topical NSAIDs for Acute Pain in Adults.” The Cochrane database of systematic reviews 6 (2010): CD007402. PMC. Web. 17 Oct. 2016.

Van Laar, Mart et al. “Pain Treatment in Arthritis-Related Pain: Beyond NSAIDs.” The Open Rheumatology Journal 6 (2012): 320–330. PMC. Web. 17 Oct. 2016.


Theodosakis J. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee. J Rheumatol. 2004;31(4):826.

Cohen M, Wolfe R, Mai T, Lewis D. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee [published correction appears in J Rheumatol. 2003;30(11):2512]. J Rheumatol. 2003;30(3):523–528.

14Arnica Oil

Wirth, James H., Hudgins, J. Craig, Paice, Judith A. Use of Herbal Therapies to Relieve Pain: A Review of Efficacy and Adverse Effects. American Society for Pain Management Nursing doi:10.1016/j.pmn.2005.08.003.

Leivers, Kevin. Unraveling the confusion around arnica’s herbal and homeopathic use. Pharmaceutical Journal, Vol 275 Sep 3. 2005.

15Lemongrass Oil

Shah, Gagan et al. “Scientific Basis for the Therapeutic Use of Cymbopogon Citratus, Stapf (Lemon Grass).” Journal of Advanced Pharmaceutical Technology & Research 2.1 (2011): 3–8. PMC. Web. 17 Oct. 2016.

Boukhatem MN, Ferhat MA, Kameli A, et al. Lemon grass (Cymbopogon citratus) essential oil as a potent anti-inflammatory and antifungal drugs. Libyan J Med. 2014;9:25431.


There’s finally a way to take control of your pain. Make Vitaproxin part of your lifestyle so you can be proactive about joint health and prevent pain from taking over your daily life.*


All of our products are made in the USA with the highest quality ingredients. All ingredients are backed by several scientific studies and clinical trials linked to improving joint health, restoring cartilage and reducing pain and inflammation.


Keep enjoying the benefits of Vitaproxin and protect your bones and joints. We’ll ship you a fresh order every month with our convenient Autoship program.


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ABOUT Vitaproxin


Chronic pain conditions, including arthritis, fibromyalgia, back pain, sciatica and other health problems affecting the bones and joints can take their toll on your daily routine and overall well-being. Enjoy an active lifestyle without joint discomfort, inflammation, and aches and pains with our breakthrough formulations. Vitaproxin is made with scientifically proven ingredients✝ linked to restoring damaged cartilage, improving joint health, and reducing inflammation.

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  • Provides temporary relief from minor aches and pains
  • Supports bone and joint health
  • Promotes joint comfort and flexibility
  • Instantly relieves acute pain
  • Supports mobility for your active lifestyle
  • Strengthens cartilage and damaged tissue
  • Reduces inflammation
  • Complements your pain management regimen